Precision Surgery

Loss of nerve function can be catastrophic. As many as 80% of prostate surgeries result in incontinence or erectile dysfunction because of nerve damage, and as many as 25% of head and neck surgeries damage the facial nerves.

The mission of Alume Biosciences is to make our proprietary nerve illumination technology available for surgeons so that patients everywhere can benefit. Learn how you can help us move surgery into the light.

Dr. Quyen Nguyen, a surgeon-scientist at the University of California at San Diego, collaborated with Nobel Laureate Dr. Roger Tsien to develop our compound, which makes nerves glow during surgery. Currently in the preclinical phase, this proprietary human nerve peptide is based on their breakthrough peptide (ALM-488) and is selective for human nerves. This research earned Dr. Nguyen a Presidential Early Career Scientist Award in 2014 and has been lauded by some of the world’s top surgeons. Human clinical trials are scheduled to begin in 2020.
administer hnp401

Before Surgery
Patient receives ALM-488 through IV 60 minutes before surgery begins. 

StepStepadminister hnp401

During Surgery
Illuminated nerves visible to the surgical team during patient surgery.

StepStepadminister alm488

After Surgery
ALM-488 is cleared through the kidneys and gone from body in hours.

  • endquoteWorking around critical nerves is 90% of head and neck surgery... Injury to the cranial nerves can result in life debilitating deficits such as facial paralysis, hoarseness, voice problems, and shoulder weakness... The potential of nerve illumination is that it will augment the surgeon's capacity to preserve these nerves and ultimately result in better function and quality-of-life outcomes for our patients. Jeremy Richmon, MD
    Harvard Medical School
    Massachusetts Eye and Ear
    Clinical Associate, Division of Head and Neck Surgery
    Director, Head and Neck Robotic Surgery
  • endquoteThe technology being developed by Alume Biosciences is interesting, and has real potential to improve the accuracy of resections and reconstructive procedures. Neural imaging could be envisioned to aid in the conduct of numerous procedures, and the underlying approach will likely have application extending beyond the initially anticipated uses. This is definitely a technology to watch.Allan D. Kirk, MD, Ph.D.
    Duke University School of Medicine Chair, Department of Surgery
    David C. Sabiston, Jr. Professor of Surgery
    Professor, Department of Immunology
    Professor, Department of Pediatrics
  • endquoteNerves are small and can be quite hard to identify during surgery, especially if there is cancer invasion, infection or trauma. The ability to see nerves using fluorescence during surgery would be a significant advance and has the potential to improve outcome in patients. Eben Rosenthal, MDStanford University Medical School
    Medical Director, Stanford Cancer Institute
    Associate Director, Clinical Care
  • endquoteNerve injury during surgery can be quite debilitating for patients. The use of a nerve illuminating compound during surgery would be a significant advance and has the potential to improve outcome in patients undergoing neurosurgical procedures. Justin M. Brown, MD
    Massachusetts General Hospital
    Director, Neurosurgery Paralysis Center
Alume Biosciences ALM-488